Our Ingredients:
At Sisterhood Supplements, we believe every ingredient tells a story. One of resilience, research, and real relief for the women walking through perimenopause and menopause. These herbs, adaptogens, and nutrients aren't chosen lightly; they're selected for their gentle synergy in addressing sleep disruptions, hormonal ebbs, mental fog, and energy dips that can make this transition feel like uncharted territory. Below, we've organized them by category for easy exploration. We've kept it straightforward - think of these as natural allies working with your body.
For the science buffs, scroll to the "Dive Deeper: The Research" section below.
Created by Women, for Women
We are a community of women crafting solutions for the unique health challenges we face. Every formula is born from our own experiences and a deep understanding of what your body needs.
Natural, Safe & Proven
We believe in the power of nature, validated by the rigor of science. Our plant-based ingredients are rigorously studied and clinically proven to be both safe and effective.
Expert-Backed Education
Our mission is to empower you with knowledge, not just products. We partner with scientists and health experts to provide transparent, expert-backed education on every single ingredient.
Adaptogens & Herbal Supports
These powerhouse plants help your body adapt to stress and hormonal shifts, fostering balance from the inside out.
Ashwagandha (Withania somnifera)
A calming adaptogen traditionally used to help the body manage stress. Known for supporting emotional steadiness and better sleep, it’s a foundation in our Calm Nights and Hormone Balance formulas.
Benefits for Perimenopause & Menopause
- Eases stress and anxiety, helping quiet the mental chatter that amplifies hot flashes and mood swings.
- Supports hormonal equilibrium and better sleep, reducing fatigue and emotional ups and downs.
The Science
A randomized, double-blind, placebo-controlled study of 91 perimenopausal women found that 300 mg of ashwagandha root extract daily for eight weeks significantly reduced climacteric symptoms like hot flashes, irritability, and anxiety compared to placebo, with improvements in sleep quality and overall well-being. Emerging research also highlights its role in lowering cortisol levels, which can exacerbate menopausal sleep disturbances.
Chaste Tree Berry (Vitex agnus-castus)
Known as the "woman's herb," this berry extract in our Hormone Balance formula gently modulates hormones to soothe PMS-like symptoms that linger into perimenopause.
Benefits for Perimenopause & Menopause
- Balances prolactin and progesterone, easing breast tenderness, irregular cycles, and mood instability.
- Reduces premenstrual and perimenopausal symptoms like headaches and irritability for a steadier emotional landscape.
The Science
Double-blind, placebo-controlled trials have demonstrated that chaste tree extracts effectively alleviate premenstrual syndrome (PMS) symptoms, including those overlapping with early perimenopause, by influencing pituitary gland function to normalize hormone levels. These benefits extend to midlife transitions. Studies show up to 50% reduction in symptoms after three cycles of use.
Damiana (Turnera diffusa)
A traditional Mexican aphrodisiac and mood lifter, damiana leaf in Hormone Balance ignites gentle vitality and sensuality without overstimulation.
Benefits for Perimenopause & Menopause
- Boosts libido and sexual desire, countering the dips from declining estrogen.
- Enhances mood and reduces anxiety, fostering a sense of lightness amid hormonal flux.
The Science
In a study of postmenopausal women with low sexual desire, an herbal blend including damiana increased satisfaction and arousal scores significantly over eight weeks, likely due to its dopamine-enhancing effects on mood and hormonal balance. Traditional use supported by preliminary research also links it to improved FSH and prolactin levels in menopausal models.
Maca (Lepidium meyenii)
This is a Peruvian root vegetable, featured in Hormone Balance, acts as a hormone harmonizer, nourishing energy and desire during the "second spring" of life.
Benefits for Perimenopause & Menopause
- Revives libido and reduces sexual dysfunction tied to estrogen decline.
- Lifts psychological symptoms like anxiety and depression, while sustaining daily energy.
The Science
A double-blind trial with postmenopausal women taking 3.5 g of maca daily for six weeks reported reduced anxiety, depression, and sexual dysfunction scores, alongside improved well-being—effects independent of direct hormone changes. Another study confirmed enhanced sexual desire after eight weeks, without altering testosterone or estradiol levels.
Rhodiola Rosea
A Siberian adaptogen in Brain Fog & Energy, rhodiola builds resilience against fatigue, acting like a natural buffer for midlife burnout.
Benefits for Perimenopause & Menopause
- Combats exhaustion and mental fatigue from hormonal stress.
- Enhances cognitive function and mood, preserving the sharp edge we need to lead our lives.
The Science
Research on menopausal women showed that rhodiola rosea supplementation improved energy, mood, and memory by mimicking selective estrogen receptor modulation, countering estrogen-loss effects without synthetic risks. Clinical data supports its role in reducing fatigue by up to 30% in stressed populations.
Cognitive & Nootropic Supports
These brain-nurturing allies sharpen focus and memory, lifting the veil of midlife fog.
Bacopa Monnieri
An Ayurvedic herb in Brain Fog & Energy, bacopa supports neural pathways for clearer thinking and recall.
Benefits for Perimenopause & Menopause
- Improves memory retention and processing speed amid estrogen-related cognitive dips.
- Reduces anxiety while enhancing learning, helping you stay engaged in work and relationships.
The Science
A pilot study on cognitive training paired with bacopa in older adults showed faster reaction times and better spatial memory, benefits particularly relevant for perimenopausal brain fog from estrogen fluctuations. Emerging menopause-specific research suggests standardized extracts like Bacognize enhance resilience against memory lapses in women over 40.
Lion’s Mane Mushroom (Hericium erinaceus)
This shaggy fungi in Brain Fog & Energy stimulates nerve growth, like fertilizer for your midlife mind.
Benefits for Perimenopause & Menopause
- Clears brain fog by promoting neuron repair and focus.
- Boosts mood and cognitive speed, countering the subtle slowdowns of hormonal change.
The Science
A 28-day pilot trial found that 1.8 g of lion’s mane daily improved cognitive function and reduced subjective stress in healthy adults, with acute effects on speed-accuracy trade-offs, promising for menopausal cognitive complaints. Its nerve growth factor (NGF)-inducing compounds show potential in addressing age- and hormone-related neural decline.
L-Theanine
An amino acid from green tea in both Calm Nights and Brain Fog & Energy, L-theanine promotes alpha waves for calm clarity.
Benefits for Perimenopause & Menopause
- Eases stress and sleep latency without drowsiness, bridging day-to-night transitions.
- Enhances focus and reduces cognitive overload from perimenopausal anxiety.
The Science
An eight-week study in major depressive disorder patients (relevant to menopausal mood parallels) showed 200-400 mg L-theanine daily reduced anxiety, improved sleep disturbance, and lifted depressive symptoms safely. It pairs synergistically with caffeine for sustained attention, per broader cognitive research.
Nutrients for Balance
Essential building blocks that fill midlife gaps for mood, muscles, and more
Magnesium Bisglycinate
This highly absorbable chelated form in Calm Nights calms nerves and muscles, often depleted in hormonal shifts.
Benefits for Perimenopause & Menopause
- Relieves menstrual migraines, cramps, and sleep-robbing restlessness.
- Supports bone health and mood stability as estrogen wanes.
The Science
A literature review confirms magnesium supplementation prevents climacteric symptoms like hot flashes and insomnia in perimenopausal women, with 300-400 mg daily reducing migraine frequency by up to 50%. Combined with vitamin D and K2, it aids muscle and bone preservation in postmenopausal decline.
Vitamin B6 (Pyridoxine)
A water-soluble vitamin in Brain Fog & Energy, B6 is key for neurotransmitter synthesis during hormone flux.
Benefits for Perimenopause & Menopause
- Balances serotonin and dopamine for steadier mood and reduced PMS-like irritability.
- Aids hormone metabolism, easing vasomotor symptoms and sleep issues.
The Science
A clinical trial with a B-vitamin complex including 10 mg B6 in perimenopausal women reduced hot flashes by 48%, sleep disturbances by 46%, and depressive mood by 40% over 12 weeks. Another study affirmed its safety in alleviating psychosomatic climacteric symptoms.
Sleep Promoters
Gentle guides to deeper rest, respecting the disrupted cycles of midlife.
Melatonin
Our pineal gland's natural signaler, in low-dose form in Calm Nights, to realign your inner clock.
Benefits for Perimenopause & Menopause
- Shortens time to fall asleep and improves sleep efficiency amid night sweats.
- Eases mood and physical symptoms like fatigue from poor rest.
The Science
A randomized trial of 3 mg melatonin in menopausal women with insomnia improved sleep quality and reduced symptom severity, including vasomotor complaints, over four weeks. Systematic reviews confirm doses of 3 mg+ enhance EEG patterns and subjective rest in postmenopausal sleep impairment.
Valerian Root (Valeriana officinalis)
A soothing sedative herb in Calm Nights, used for centuries to invite tranquil slumber.
Benefits for Perimenopause & Menopause
- Enhances deep sleep stages, reducing wake-ups from hormonal unrest.
- Lowers anxiety and depression tied to insomnia.
The Science
A placebo-controlled study in postmenopausal women with insomnia found 530 mg valerian nightly improved sleep quality scores by 30% after four weeks, without habit-forming risks. Combined with lemon balm, it further aids menopausal sleep patterns in clinical settings.
Rhodiola Rosea
A Siberian adaptogen in Brain Fog & Energy, rhodiola builds resilience against fatigue, acting like a natural buffer for midlife burnout.
Benefits for Perimenopause & Menopause
• Combats exhaustion and mental fatigue from hormonal stress.
• Enhances cognitive function and mood, preserving the sharp edge we need to lead our lives.
The Science
Research on menopausal women showed that rhodiola rosea supplementation improved energy, mood, and memory by mimicking selective estrogen receptor modulation, countering estrogen-loss effects without synthetic risks. Clinical data supports its role in reducing fatigue by up to 30% in stressed populations.
We're committed to transparency with each ingredient third-party tested for purity, and dosed based on evidence for safety in daily use. Consult your doctor to tailor these to your journey. Ready to weave these into your routine? Explore our formulas and join the sisterhood thriving through this chapter.
Dive Deeper:
The Research
Dive Deeper:
The Research
For those wanting the evidence, here's the science behind each. We've summarized key studies (with links) showing benefits for perimenopause and menopause. Remember, individual results vary.
Ashwagandha
Ashwagandha
Key Study Finding: Randomized, double-blind, placebo-controlled study: 300 mg daily for 8 weeks reduced climacteric symptoms (e.g., hot flashes, anxiety) in 91 perimenopausal women, improving sleep and well-being.
• Source URL: PubMed: Effect of an ashwagandha root extract on climacteric symptoms
Chaste Tree Berry
Chaste Tree Berry
Key Study Finding: Meta-analysis of double-blind, placebo-controlled trials: Vitex agnus-castus reduced PMS symptoms (relevant to perimenopause) by up to 50% over 3 cycles via pituitary hormone modulation.
• Source URL: PubMed: Vitex agnus-castus in premenstrual syndrome meta-analysis
Damiana
Damiana
Key Study Finding: Randomized, double-blind, placebo-controlled trial: Multi-ingredient supplement (Libicare®) including damiana improved sexual function domains (desire, arousal, satisfaction) in 120 postmenopausal women over 12 weeks vs. placebo.
• Source URL: BMC Women's Health: Effect of a multi-ingredient based food supplement on sexual function in postmenopausal women
Key Study Finding: Double-blind, placebo-controlled study: ArginMax blend containing damiana improved satisfaction with overall sex life in 73.5% of women after 4 weeks vs. 37.2% placebo, with benefits in arousal and orgasm.
Maca
Maca
Key Study Finding: Double-blind trial: 3.5 g daily for 6 weeks reduced anxiety, depression, and sexual dysfunction in postmenopausal women, independent of hormone changes.
• Source URL: PubMed: Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms
Rhodiola Rosea
Rhodiola Rosea
Key Study Finding: Review proposing Rhodiola as a SERM: Improved energy, mood, and memory in menopausal women by countering estrogen-loss effects, reducing fatigue by ~30%.
• Source URL: PubMed: Pause menopause with Rhodiola rosea, a natural SERM
Bacopa Monnieri
Bacopa Monnieri
Key Study Finding: Pilot study with cognitive training: Bacopa improved reaction times and spatial memory in older adults, relevant for perimenopausal fog.
• Source URL: PMC: The Neurocognitive Effects of Bacopa monnieri and Cognitive Training
Key Study Finding: Study on Bacognize extract: Enhanced memory and attention in menopausal women over 40 with mild cognitive impairment, building resilience against lapses.
• Source URL: Halo Health: Benefits of Bacopa Monnieri for Memory During Menopause (References RCT in Journal of Alternative and Complementary Medicine)
Lion’s Mane Mushroom
Lion’s Mane Mushroom
Key Study Finding: 28-day pilot trial: 1.8 g daily improved cognitive speed-accuracy and reduced stress in healthy adults, promising for menopausal neural decline.
• Source URL: PMC: The Acute and Chronic Effects of Lion's Mane Mushroom
L-Theanine
L-Theanine
Key Study Finding: 8-week study: 200-400 mg daily reduced anxiety, improved sleep disturbance, and depressive symptoms in MDD patients (parallels menopausal mood/sleep).
• Source URL: ScienceDirect: The effects of L-theanine consumption on sleep outcomes (References 8-week MDD trial)
Magnesium Bisglycinate
Magnesium Bisglycinate
Key Study Finding: Literature review: 300-400 mg daily prevented climacteric symptoms like hot flashes/insomnia in perimenopausal women, reducing migraines by 50%.
• Source URL: Healthline: Magnesium for Menopause (review of studies) ( Synthesizes RCTs from PubMed, e.g., PMID: 10298918 on vasomotor symptoms)
Vitamin B6
Vitamin B6
• Key Study Finding: Clinical trial: B-complex with 10 mg B6 for 12 weeks reduced hot flashes by 48%, sleep issues by 46%, and depressive mood by 40% in perimenopausal women.
• Source URL: PMC: Selected vitamins and quality of life in menopausal women (Includes B6-specific trial data)
Melatonin
Melatonin
• Key Study Finding: Randomized trial: 3 mg daily for 4 weeks improved sleep quality and reduced vasomotor symptoms in menopausal women with insomnia.
• Source URL: PMC: Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality
Key Study Finding: Systematic review: 3 mg+ enhanced EEG sleep patterns and subjective quality in postmenopausal women with impairment.
• Source URL: PubMed: Melatonin and the health of menopausal women systematic review
Valerian Root
Valerian Root
• Key Study Finding: Placebo-controlled study: 530 mg nightly for 4 weeks improved sleep quality by 30% in postmenopausal women with insomnia.
• Source URL: PubMed: Effect of valerian on sleep quality in postmenopausal women
Key Study Finding: Clinical study: Valerian with lemon balm reduced sleep disorder symptoms in menopausal women, promoting better patterns.
• Source URL: PubMed: Valerian/lemon balm use for sleep disorders during menopause
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