Skip to content
Knowledge is Power
Strength in Sisterhood
Solutions that Work

Our Ingredients:

Science-Backed Allies for Your Midlife Journey

At Sisterhood Supplements, we believe every ingredient tells a story. One of resilience, research, and real relief for the women walking through perimenopause and menopause. These herbs, adaptogens, and nutrients aren't chosen lightly; they're selected for their gentle synergy in addressing sleep disruptions, hormonal ebbs, mental fog, and energy dips that can make this transition feel like uncharted territory. Below, we've organized them by category for easy exploration. We've kept it straightforward - think of these as natural allies working with your body.

For the science buffs, scroll to the "Dive Deeper: The Research" section below.

Created by Women, for Women

Created by Women, for Women

We are a community of women crafting solutions for the unique health challenges we face. Every formula is born from our own experiences and a deep understanding of what your body needs.

Natural, Safe & Proven

Natural, Safe & Proven

We believe in the power of nature, validated by the rigor of science. Our plant-based ingredients are rigorously studied and clinically proven to be both safe and effective.

Expert-Backed Education

Expert-Backed Education

Our mission is to empower you with knowledge, not just products. We partner with scientists and health experts to provide transparent, expert-backed education on every single ingredient.

Non GMO
100% Organic
VEGAN
GMP - 'Good Manufacturing Practice' Certified
NSF

Adaptogens & Herbal Supports

These powerhouse plants help your body adapt to stress and hormonal shifts, fostering balance from the inside out.

Ashwagandha (Withania somnifera) 

Ashwagandha (Withania somnifera) 

A calming adaptogen traditionally used to help the body manage stress. Known for supporting emotional steadiness and better sleep, it’s a foundation in our Calm Nights and Hormone Balance formulas.

Benefits for Perimenopause & Menopause

  • Eases stress and anxiety, helping quiet the mental chatter that amplifies hot flashes and mood swings.
  • Supports hormonal equilibrium and better sleep, reducing fatigue and emotional ups and downs.

The Science
A randomized, double-blind, placebo-controlled study of 91 perimenopausal women found that 300 mg of ashwagandha root extract daily for eight weeks significantly reduced climacteric symptoms like hot flashes, irritability, and anxiety compared to placebo, with improvements in sleep quality and overall well-being. Emerging research also highlights its role in lowering cortisol levels, which can exacerbate menopausal sleep disturbances.

Chaste Tree Berry (Vitex agnus-castus)

Chaste Tree Berry (Vitex agnus-castus)

Known as the "woman's herb," this berry extract in our Hormone Balance formula gently modulates hormones to soothe PMS-like symptoms that linger into perimenopause.

Benefits for Perimenopause & Menopause

  • Balances prolactin and progesterone, easing breast tenderness, irregular cycles, and mood instability.
  • Reduces premenstrual and perimenopausal symptoms like headaches and irritability for a steadier emotional landscape.

The Science
Double-blind, placebo-controlled trials have demonstrated that chaste tree extracts effectively alleviate premenstrual syndrome (PMS) symptoms, including those overlapping with early perimenopause, by influencing pituitary gland function to normalize hormone levels. These benefits extend to midlife transitions. Studies show up to 50% reduction in symptoms after three cycles of use.

Damiana (Turnera diffusa)

Damiana (Turnera diffusa)

A traditional Mexican aphrodisiac and mood lifter, damiana leaf in Hormone Balance ignites gentle vitality and sensuality without overstimulation.

Benefits for Perimenopause & Menopause

  • Boosts libido and sexual desire, countering the dips from declining estrogen.
  • Enhances mood and reduces anxiety, fostering a sense of lightness amid hormonal flux.

The Science
In a study of postmenopausal women with low sexual desire, an herbal blend including damiana increased satisfaction and arousal scores significantly over eight weeks, likely due to its dopamine-enhancing effects on mood and hormonal balance. Traditional use supported by preliminary research also links it to improved FSH and prolactin levels in menopausal models.

Maca (Lepidium meyenii)

Maca (Lepidium meyenii)

This is a Peruvian root vegetable, featured in Hormone Balance, acts as a hormone harmonizer, nourishing energy and desire during the "second spring" of life.

Benefits for Perimenopause & Menopause

  • Revives libido and reduces sexual dysfunction tied to estrogen decline.
  • Lifts psychological symptoms like anxiety and depression, while sustaining daily energy.

The Science
A double-blind trial with postmenopausal women taking 3.5 g of maca daily for six weeks reported reduced anxiety, depression, and sexual dysfunction scores, alongside improved well-being—effects independent of direct hormone changes. Another study confirmed enhanced sexual desire after eight weeks, without altering testosterone or estradiol levels.

Rhodiola Rosea

Rhodiola Rosea

A Siberian adaptogen in Brain Fog & Energy, rhodiola builds resilience against fatigue, acting like a natural buffer for midlife burnout.

Benefits for Perimenopause & Menopause

  • Combats exhaustion and mental fatigue from hormonal stress.
  • Enhances cognitive function and mood, preserving the sharp edge we need to lead our lives.

The Science
Research on menopausal women showed that rhodiola rosea supplementation improved energy, mood, and memory by mimicking selective estrogen receptor modulation, countering estrogen-loss effects without synthetic risks. Clinical data supports its role in reducing fatigue by up to 30% in stressed populations.

Cognitive & Nootropic Supports

These brain-nurturing allies sharpen focus and memory, lifting the veil of midlife fog.

Bacopa Monnieri

Bacopa Monnieri

An Ayurvedic herb in Brain Fog & Energy, bacopa supports neural pathways for clearer thinking and recall.

Benefits for Perimenopause & Menopause

  • Improves memory retention and processing speed amid estrogen-related cognitive dips.
  • Reduces anxiety while enhancing learning, helping you stay engaged in work and relationships.

The Science
A pilot study on cognitive training paired with bacopa in older adults showed faster reaction times and better spatial memory, benefits particularly relevant for perimenopausal brain fog from estrogen fluctuations. Emerging menopause-specific research suggests standardized extracts like Bacognize enhance resilience against memory lapses in women over 40.

Lion’s Mane Mushroom (Hericium erinaceus)

Lion’s Mane Mushroom (Hericium erinaceus)

This shaggy fungi in Brain Fog & Energy stimulates nerve growth, like fertilizer for your midlife mind.

Benefits for Perimenopause & Menopause

  • Clears brain fog by promoting neuron repair and focus.
  • Boosts mood and cognitive speed, countering the subtle slowdowns of hormonal change.

The Science
A 28-day pilot trial found that 1.8 g of lion’s mane daily improved cognitive function and reduced subjective stress in healthy adults, with acute effects on speed-accuracy trade-offs, promising for menopausal cognitive complaints. Its nerve growth factor (NGF)-inducing compounds show potential in addressing age- and hormone-related neural decline.

L-Theanine

L-Theanine

An amino acid from green tea in both Calm Nights and Brain Fog & Energy, L-theanine promotes alpha waves for calm clarity.

Benefits for Perimenopause & Menopause

  • Eases stress and sleep latency without drowsiness, bridging day-to-night transitions.
  • Enhances focus and reduces cognitive overload from perimenopausal anxiety.

The Science
An eight-week study in major depressive disorder patients (relevant to menopausal mood parallels) showed 200-400 mg L-theanine daily reduced anxiety, improved sleep disturbance, and lifted depressive symptoms safely. It pairs synergistically with caffeine for sustained attention, per broader cognitive research.

Nutrients for Balance

Essential building blocks that fill midlife gaps for mood, muscles, and more

Magnesium Bisglycinate

Magnesium Bisglycinate

This highly absorbable chelated form in Calm Nights calms nerves and muscles, often depleted in hormonal shifts.

Benefits for Perimenopause & Menopause

  • Relieves menstrual migraines, cramps, and sleep-robbing restlessness.
  • Supports bone health and mood stability as estrogen wanes.

The Science
A literature review confirms magnesium supplementation prevents climacteric symptoms like hot flashes and insomnia in perimenopausal women, with 300-400 mg daily reducing migraine frequency by up to 50%. Combined with vitamin D and K2, it aids muscle and bone preservation in postmenopausal decline.

Vitamin B6 (Pyridoxine)

Vitamin B6 (Pyridoxine)

A water-soluble vitamin in Brain Fog & Energy, B6 is key for neurotransmitter synthesis during hormone flux.

Benefits for Perimenopause & Menopause

  • Balances serotonin and dopamine for steadier mood and reduced PMS-like irritability.
  • Aids hormone metabolism, easing vasomotor symptoms and sleep issues.

The Science
A clinical trial with a B-vitamin complex including 10 mg B6 in perimenopausal women reduced hot flashes by 48%, sleep disturbances by 46%, and depressive mood by 40% over 12 weeks. Another study affirmed its safety in alleviating psychosomatic climacteric symptoms.

Sleep Promoters

Gentle guides to deeper rest, respecting the disrupted cycles of midlife.

Melatonin

Melatonin

Our pineal gland's natural signaler, in low-dose form in Calm Nights, to realign your inner clock.

Benefits for Perimenopause & Menopause

  • Shortens time to fall asleep and improves sleep efficiency amid night sweats.
  • Eases mood and physical symptoms like fatigue from poor rest.

The Science
A randomized trial of 3 mg melatonin in menopausal women with insomnia improved sleep quality and reduced symptom severity, including vasomotor complaints, over four weeks. Systematic reviews confirm doses of 3 mg+ enhance EEG patterns and subjective rest in postmenopausal sleep impairment.

Valerian Root (Valeriana officinalis)

Valerian Root (Valeriana officinalis)

A soothing sedative herb in Calm Nights, used for centuries to invite tranquil slumber.

Benefits for Perimenopause & Menopause

  • Enhances deep sleep stages, reducing wake-ups from hormonal unrest.
  • Lowers anxiety and depression tied to insomnia.

The Science
A placebo-controlled study in postmenopausal women with insomnia found 530 mg valerian nightly improved sleep quality scores by 30% after four weeks, without habit-forming risks. Combined with lemon balm, it further aids menopausal sleep patterns in clinical settings.

Rhodiola Rosea

Rhodiola Rosea

A Siberian adaptogen in Brain Fog & Energy, rhodiola builds resilience against fatigue, acting like a natural buffer for midlife burnout.

Benefits for Perimenopause & Menopause

• Combats exhaustion and mental fatigue from hormonal stress.
• Enhances cognitive function and mood, preserving the sharp edge we need to lead our lives.

The Science

Research on menopausal women showed that rhodiola rosea supplementation improved energy, mood, and memory by mimicking selective estrogen receptor modulation, countering estrogen-loss effects without synthetic risks. Clinical data supports its role in reducing fatigue by up to 30% in stressed populations.

We're committed to transparency with each ingredient third-party tested for purity, and dosed based on evidence for safety in daily use. Consult your doctor to tailor these to your journey. Ready to weave these into your routine? Explore our formulas and join the sisterhood thriving through this chapter.

Dive Deeper:
The Research

For those wanting the evidence, here's the science behind each. We've summarized key studies (with links) showing benefits for perimenopause and menopause. Remember, individual results vary.

Ready to Feel Your Best?

Explore our full range of science-backed, natural supplements designed to support women's health and wellness.

Shop Our Products